Turning Internal Oncogenic Overdrive into Cell-Surface Targets
Targeted oncology remains constrained by shared surface antigens and therapy-induced apoptotic resistance. Thirai Bio engineers inside-out biophysical logic gates that evaluate intracellular kinase flux to autonomously unmask synthetic surface beacons for precision immune clearance.
Inside-Out Precision Architecture: Translating intracellular multi-kinase signaling cascades into mechanical cell-surface neo-epitope projection.
The Surface Antigen Bottleneck
Nearly all solid-tumor surface targets are expressed at basal levels on essential healthy organs. Conventional outside-in therapies trigger on-target, off-tumor toxicities that constrain therapeutic windows.
Computing from the Inside Out
Rather than relying on passive surface expression or attempting to inhibit pan-cell-cycle engines, we convert cancer's internal enzymatic overdrive into a mechanical trigger that hoists an orthogonal surface beacon.
Decoupled Biologics
By decoupling intracellular oncogenic signal sensing from immune cell recruitment, the platform achieves high discrimination, avoids systemic off-target damage, and operates via scalable bioprocess economics.
Translational Oncology & Computational Biophysics
Architected by researchers from the University of Michigan and University of California, San Francisco (UCSF) with over 26 years of combined expertise across cell-cycle regulation, oncogenic kinase networks, macromolecular simulation, and allosteric protein design.